Methylcobalamin is basically vitamin B12 which is obtained from the bacteria. This vitamin is important for the synthesis of deoxyribonucleic acid and for energy production. It aids in the growth and reproduction of the cells. Deficiency of this vitamin is responsible for occurrence of neurological diseases.
Pernicious anemia
Vitamin B12 deficiency
In pregnancy
Haemolytic anemia
Vitamin B12 act as cofactor for the methionine synthase which is the important for the synthesis of purines and pyrimidines. these purines and pyrimidines further form DNA. L-metylmalonyl CoA is formed by the conversion of L-metylmalonyl CoA mutase to succinyl-CoA as, this step is essential for metabolism of fat and proteins.
Absorption-
It is absorbed slowly through oral administration and absorbs fastly through Intramuscular and subcutaneous route
Protein Binding-
It shows high plasma proteins binding.
Metabolism-
It is metabolized in the liver
Excretion-
It is excreted via urine
Common side effects of the injection includes:
Dizziness
Headache
Anxiety
Nausea
Vomiting
Gentamycin
Neomycin
Phenytoin
Contraindicated in atrophic gastritis
Contraindicated in leber’s heredity
| Methylcobalamin | 1000 mcg |