Fluconazole is an antifungal medicine used to treat the symptoms of fungal infections. It is also used in the treatment of meningitis caused by fungus and to prevent yeast infections in patients who become infected due to treatment with chemotherapy or radiation therapy. Fluconazole belongs to a class of antifungals called triazoles. It acts by retarding the growth of fungi that cause infection. It could also be used alone or with other medications.
Vaginal candidiasis
Oropharyngeal and esophageal candidiasis
Cryptococcal meningitis
Fluconazole is a very selective inhibitor of fungal cytochrome p450 dependent enzyme lanosterol 14-α-demethylase which functions to convert lanosterol to ergosterol that is essential for fungal cell wall synthesis. Binding takes place between free nitrogen atom located on azole ring of fluconazole with a single iron atom located in the heme group of lanosterol 14-α-demethylase. This prevents oxygen activation and thus inhibits the demethylation of lanosterol, retarding the process of ergosterol biosynthesis. Methylated sterols accumulate in the fungal cellular membrane, leading to an arrest of fungal growth. These accumulated sterols negatively affect the structure and function of the fungal cell plasma membrane.
Fluconazole resistance may arise from an alteration in the amount or function of the target enzyme, altered access to this enzyme, or a combination of the above.
Absorption: following oral dosing, fluconazole is almost rapidly absorbed within two hours.
Distribution: it is widely distributed throughout the body, with good penetration into csf, eye, sputum, peritoneal fluid, skin and urine.
Metabolism: plasma elimination half-life for fluconazole is approximately 30 hours.
Excretion: The major route of excretion is renal, with approximately 80% of the administered dose appearing in the urine as unchanged medicinal product.
Nausea, stomach pain, diarrhea, upset stomach
Headache
Dizziness
Changes in your sense of taste
Shortness of breath
Fever, chills, body aches
Flu symptoms
Easy bruising or bleeding
Seizure
Skin rash or skin lesions
Liver problems
Use with caution in patients with hepatic impairment.
Do not take diflucan if you'r allergic to fluconazole or any ingredients in this drug.
While driving vehicles or operating machines, dizziness or seizures may occasionally occur.
In case of patients with renal dysfunction consult with physician.
Advisable to consult physician in patients with potentially proarrhythmic conditions.
Do not take diflucan if you'r allergic to fluconazole or any ingredients in this drug.
| Fluconazole | 150 mg |